Taste-Masking Cross-Linked Polymer
Tanmask
The Tanmask range is derived from cross-linked polyacrylic polymers used in the pharmaceutical industry to mask the taste of bitter drugs and to stabilize them. It is a white to off-white, fine, water-swellable powder.
Taste-masked complexes of bitter drugs can be used in suspensions (immediate and extended release), dry syrups, and mouth-dissolving, dispersible and chewable tablets.
Applications
Suspensions, dry syrup, dispersible & chewable tablets, MDT
01
Traditional grades
| T-114 | T-134 | T-504 | T-548 | |
|---|---|---|---|---|
| Pharmacopoeia | In house | Polacrilin Potassium USP/NF | Sodium Polystyrene Sulfonate USP/NF | Calcium Polystyrene Sulfonate BP |
| Type | Weak acid | Weak acid | Strong acid | Strong acid |
| Functionality | –COO | –COO | –SO₃ | –SO₃ |
| Ionic form | Hydrogen | Potassium | Sodium | Calcium |
| Matrix | Polyacrylic copolymer | Polyacrylic copolymer | Polystyrene copolymer | Polystyrene copolymer |
| Moisture content | < 5% | < 10% | < 10% | < 10% |
| Appearance | White to off-white free-flowing powder | White to off-white free-flowing powder | Golden brown free-flowing powder | Cream to light brown free-flowing powder |
| Drugs to be masked | Dextromethorphan HBr, Dicyclomine HCl, Domperidone, Carbonyl Iron, Erdosteine, etc. | Ambroxol HCl, Amodiaquine HCl, Artemether, Lumefantrine, Sparfloxacin, etc. | Erythromycin Ethyl Succinate, Aceclofenac, Ranitidine HCl, etc. | Hyperkalemia (as an active) |
02
Tanmask T-314 — Polacrilin Potassium
Derived from a cross-linked polymer of polycarboxylic acids per USP/NF, in K⁺ ionic form. A very high-purity polymer used as a super-fast disintegrant and dissolution improver in tablets, capsules and pellets; suitable for both wet granulation and direct compression. Specially designed for acidic drugs.
As a disintegrating agent
Very high swelling on contact with water or GI fluids, giving fast disintegration without lump formation. Use at 0.5–4.0%, during mixing and/or at the lubrication stage.
Applications Immediate-release tablets, herbal tablets, mouth-dissolving tablets
As a dissolution improver
Breaks tablets into very small particles, increasing effective surface area for absorption and so dissolution and bioavailability. Use at 2.0–10.0%.
Applications Cefuroxime Axetil, Cefpodoxime Proxetil, Atorvastatin Calcium, Telmisartan, Glimepiride, Gliclazide, Ondansetron